Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

被引：59
|
作者：
Sharley, Daniel D. Sanz [1 ]
Williams, Jonathan M. J. [1 ]
机构：
[1] Univ Bath, Dept Chem, Claverton Down, Bath BA2 7AY, Avon, England
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 12期
基金：
英国工程与自然科学研究理事会;
关键词：
NONACTIVATED CARBOXYLIC-ACIDS; DIRECT AMIDATION; AMIDE FORMATION; ACETYLATION; TRANSAMIDATION; ALCOHOLS;
D O I：
10.1039/c6cc09023k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 degrees C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 degrees C.
引用
收藏
页码：2020 / 2023
页数：4
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