Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

被引：59

作者：

Sharley, Daniel D. Sanz ^{[1
]}

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Claverton Down, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

NONACTIVATED CARBOXYLIC-ACIDS; DIRECT AMIDATION; AMIDE FORMATION; ACETYLATION; TRANSAMIDATION; ALCOHOLS;

D O I：

10.1039/c6cc09023k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 degrees C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 degrees C.

引用

页码：2020 / 2023

页数：4

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