Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

被引：9
|
作者：
Bean, LeDon
Zheng, Hong
Patel, Kaushik P.
Monaghan, Daniel T.
机构：
[1] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA
来源：
BRAIN RESEARCH | 2006年 / 1115卷
关键词：
D O I：
10.1016/j.brainres.2006.07.090
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of L-[H-3] glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：217 / 222
页数：6
相关论文
共 50 条
  • [41] Altered regional hemodynamics in the streptozotocin diabetic rat
    Misurski, D
    Bardal, S
    Gopalakrishnan, V
    McNeill, JR
    JOURNAL OF HYPERTENSION, 2002, 20 : S210 - S210
  • [42] SYSTEMIC AND REGIONAL HEMODYNAMICS IN THE STREPTOZOTOCIN DIABETIC RAT
    CHAROCOPOS, F
    GAVRAS, I
    BRUNNER, HR
    GAVRAS, H
    CLINICAL RESEARCH, 1982, 30 (02): : A509 - A509
  • [43] RESTORATION OF GLYCOGEN-SYNTHESIS IN PERFUSED LIVER OF STREPTOZOTOCIN-DIABETIC RAT
    WHITTON, PD
    HEMS, DA
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1974, 2 (05) : 917 - 920
  • [44] HYPERPLASIA OF THE MESENTERIAL WINDOWS PRECEDES THAT OF THE SMALL GUT IN THE STREPTOZOTOCIN-DIABETIC RAT
    BERGSTROM, S
    NORRBY, K
    APMIS, 1988, 96 (05) : 407 - 414
  • [45] Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat
    Degenhardt, TP
    Alderson, NL
    Arrington, DD
    Beattie, RJ
    Basgen, JM
    Steffes, MW
    Thorpe, SR
    Baynes, JW
    KIDNEY INTERNATIONAL, 2002, 61 (03) : 939 - 950
  • [46] REDUCTION IN BRAIN-SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS
    CRANDALL, EA
    GILLIS, MA
    FERNSTROM, JD
    ENDOCRINOLOGY, 1981, 109 (01) : 310 - 312
  • [47] CATION PERMEABILITY OF THE BLOOD-BRAIN-BARRIER IN STREPTOZOTOCIN-DIABETIC RATS
    JAKOBSEN, J
    KNUDSEN, GM
    JUHLER, M
    DIABETOLOGIA, 1987, 30 (06) : 409 - 413
  • [48] Effects of sitagliptin on β-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta
    Muderrisoglu, Ayhanim Elif
    Erdogan, Betul Rabia
    Yesilyurt, Zeynep Elif
    Boztas, Ceren Uyar
    Karacomerlioglu, Irem
    Altan, Vecdi Melih
    Inan, Ebru Arioglu
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2021, 51 (02) : 864 - 872
  • [49] REDUCED BRAIN-SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS
    CRANDALL, EA
    FERNSTROM, JD
    FEDERATION PROCEEDINGS, 1981, 40 (03) : 266 - 266
  • [50] GLUCOSE-TRANSPORT ACROSS OCULAR BARRIERS OF THE STREPTOZOTOCIN-DIABETIC RAT
    DIMATTIO, J
    ALTSZULER, N
    ELLIS, S
    ZADUNAISKY, JA
    DIABETES, 1981, 30 (11) : 903 - 906
12345