Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

被引：9
|
作者：
Bean, LeDon
Zheng, Hong
Patel, Kaushik P.
Monaghan, Daniel T.
机构：
[1] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA
来源：
BRAIN RESEARCH | 2006年 / 1115卷
关键词：
D O I：
10.1016/j.brainres.2006.07.090
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of L-[H-3] glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：217 / 222
页数：6
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