Synthesis of novel 4-(5′-pyrrolidinyl)-β-lactams

被引：45
|
作者：
Grigg, R [1 ]
Thornton-Pett, M [1 ]
Xu, J [1 ]
Xu, LH [1 ]
机构：
[1] Univ Leeds, Sch Chem, Mol Innovat Divers & Automated Synth Ctr, Leeds LS2 9JT, W Yorkshire, England
来源：
TETRAHEDRON | 1999年 / 55卷 / 48期
关键词：
beta-lactams; azomethine ylide; cycloaddition; cascade reaction;
D O I：
10.1016/S0040-4020(99)00867-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of novel 4-(5'-pynolidinyl)-beta-lactams from imines derived from 4-formyl-beta-lactams and alpha-amino esters via cascade imine-->azomethine ylide-->1,3-dipolar cycloaddition reactions is described. These cascades are endo-specific, exhibit facial stereoselectivity and occur in good to excellent yields. (C) 1999 Elsevier Science Ltd. Ail rights reserved.
引用
收藏
页码：13841 / 13866
页数：26
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