Forensic toxicology:: development of an SNP-assay for genotyping CYP2D6 and CYP2C19 variants

被引：1
|
作者：
Verrecas, M [1 ]
Knaepen, K [1 ]
Gifissen, A [1 ]
Cassiman, J [1 ]
Decorte, R [1 ]
机构：
[1] Katholieke Univ Leuven, Dept Human Genet, Lab Forens Genet & Mol Archaeol, B-3000 Louvain, Belgium
来源：
PROGRESS IN FORENSIC GENETICS 10 | 2004年 / 1261卷
关键词：
pharmacogenetics; single nucleotide polymorphism; mini-sequencing; cytochrome p450;
D O I：
10.1016/S0531-5131(03)01775-8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A procedure was developed for genotyping one CYP2C19 and eight CYP2D6 polymorphisms. After multiplex PCR of the exons containing the SNPs, a mini-sequencing reaction was performed with the SNapShot(TM) Multiplex Kit and the resultant primer-extension products were analyzed on an ABI PRISM(R) 3100 Genetic Analyzer. The developed procedure was validated in a population of 199 Caucasians. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：583 / 585
页数：3
相关论文
共 50 条
  • [41] Frequencies of CYP2C19 and CYP2D6 gene variants in a German inpatient sample with mood and anxiety disorders
    Scherf-Clavel, Maike
    Weber, Heike
    Unterecker, Stefan
    Mueller, Daniel J.
    Deckert, Juergen
    WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2024, 25 (04): : 214 - 221
  • [42] SNP genotyping using TaqMan® technology: the CYP2D6*17 assay conundrum
    Gaedigk, Andrea
    Freeman, Natalie
    Hartshorne, Toinette
    Riffel, Amanda K.
    Irwin, David
    Bishop, Jeffrey R.
    Stein, Mark A.
    Newcorn, Jeffrey H.
    Jaime, Lazara Karelia Montane
    Cherner, Mariana
    Leeder, J. Steven
    SCIENTIFIC REPORTS, 2015, 5
  • [43] Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder
    E J Brandl
    A K Tiwari
    X Zhou
    J Deluce
    J L Kennedy
    D J Müller
    M A Richter
    The Pharmacogenomics Journal, 2014, 14 : 176 - 181
  • [44] Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder
    Brandl, E. J.
    Tiwari, A. K.
    Zhou, X.
    Deluce, J.
    Kennedy, J. L.
    Mueller, D. J.
    Richter, M. A.
    PHARMACOGENOMICS JOURNAL, 2014, 14 (02): : 176 - 181
  • [45] Pharmacogenetic variation at CYP2C9, CYP2C19, and CYP2D6 at global and microgeographic scales
    Sistonen, Johanna
    Fuselli, Silvia
    Palo, Jukka U.
    Chauhan, Neelam
    Padh, Harish
    Sajantila, Antti
    PHARMACOGENETICS AND GENOMICS, 2009, 19 (02): : 170 - 179
  • [46] CYP2C9, CYP2C19 and CYP2D6 allele frequencies in the Ashkenazi Jewish population
    Scott, StuartA
    Edelmann, Lisa
    Kornreich, Rutb
    Erazo, Monica
    Desnick, Robert J.
    PHARMACOGENOMICS, 2007, 8 (07) : 721 - 730
  • [47] The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics
    Giorgetti, Arianna
    Amurri, Sara
    Fazio, Giulia
    Bini, Carla
    Anniballi, Laura
    Pirani, Filippo
    Pelletti, Guido
    Pelotti, Susi
    METABOLITES, 2023, 13 (05)
  • [48] PREVALENCE OF CYP2D6, CYP2C9 AND CYP2C19 ALLELIC VARIANTS IN A PEDIATRIC SICKLE CELL DISEASE PATIENT COHORT
    Vega, Roger
    Scott, Stuart
    Patel, Niren
    Xu, Hongyan
    Kutlar, Abdullah
    AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (12) : E19 - E20
  • [49] Use of oligonucleotide array hybridization for genotyping CYP2D6 and CYP2C19.
    Hahnenberger, KM
    Lin, C
    Atwell, AS
    Ryder, TB
    Liu, WW
    Sampas, NM
    Cattell, HF
    Kanemoto, R
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1997, 61 (02) : OIB3 - OIB3
  • [50] Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
    Rodrigues-Soares, Fernanda
    Penas-Lledo, Eva M.
    Tarazona-Santos, Eduardo
    Sosa-Macias, Martha
    Teran, Enrique
    Lopez-Lopez, Marisol
    Rodeiro, Idania
    Moya, Graciela E.
    Calzadilla, Luis R.
    Ramirez-Roa, Ronald
    Grazina, Manuela
    Estevez-Carrizo, Francisco E.
    Barrantes, Ramiro
    LLerena, Adrian
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2020, 107 (01) : 257 - 268
12345