Forensic toxicology:: development of an SNP-assay for genotyping CYP2D6 and CYP2C19 variants

被引：1
|
作者：
Verrecas, M [1 ]
Knaepen, K [1 ]
Gifissen, A [1 ]
Cassiman, J [1 ]
Decorte, R [1 ]
机构：
[1] Katholieke Univ Leuven, Dept Human Genet, Lab Forens Genet & Mol Archaeol, B-3000 Louvain, Belgium
来源：
PROGRESS IN FORENSIC GENETICS 10 | 2004年 / 1261卷
关键词：
pharmacogenetics; single nucleotide polymorphism; mini-sequencing; cytochrome p450;
D O I：
10.1016/S0531-5131(03)01775-8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A procedure was developed for genotyping one CYP2C19 and eight CYP2D6 polymorphisms. After multiplex PCR of the exons containing the SNPs, a mini-sequencing reaction was performed with the SNapShot(TM) Multiplex Kit and the resultant primer-extension products were analyzed on an ABI PRISM(R) 3100 Genetic Analyzer. The developed procedure was validated in a population of 199 Caucasians. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：583 / 585
页数：3
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