Forensic toxicology:: development of an SNP-assay for genotyping CYP2D6 and CYP2C19 variants

被引：1

作者：

Verrecas, M ^{[1
]}

Knaepen, K ^{[1
]}

Gifissen, A ^{[1
]}

Cassiman, J ^{[1
]}

Decorte, R ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Human Genet, Lab Forens Genet & Mol Archaeol, B-3000 Louvain, Belgium

来源：

PROGRESS IN FORENSIC GENETICS 10 | 2004年 / 1261卷

关键词：

pharmacogenetics; single nucleotide polymorphism; mini-sequencing; cytochrome p450;

D O I：

10.1016/S0531-5131(03)01775-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A procedure was developed for genotyping one CYP2C19 and eight CYP2D6 polymorphisms. After multiplex PCR of the exons containing the SNPs, a mini-sequencing reaction was performed with the SNapShot(TM) Multiplex Kit and the resultant primer-extension products were analyzed on an ABI PRISM(R) 3100 Genetic Analyzer. The developed procedure was validated in a population of 199 Caucasians. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：583 / 585

页数：3

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