Two new sesquiterpene lactones from the fruits of Illicium jiadifengpi

被引：7
|
作者：
Liu, Jifeng [1 ]
Liu, Feiyan [1 ]
Zhang, Nenling [2 ]
Wang, Yafeng [1 ,3 ]
Yang, Lijia [1 ]
Bi, Yuefeng [1 ]
Zhang, Yanbing [1 ]
Liu, Mengqi [4 ]
机构：
[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
[2] Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
[3] Zhengzhou Univ, Acad Med & Pharmaceut Sci, Henan Key Lab Pharmacol Liver Dis, Zhengzhou 450052, Peoples R China
[4] Henan Univ Tradit Chinese Med, Sch Pharmaceut Sci, Zhengzhou 450008, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Illicium jiadifengpi; sesquiterpene lactones; anti-HBV activity; NEUROTROPHIC ACTIVITY; ROOTS;
D O I：
10.1080/14786419.2015.1058793
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 +/- 3.09% and 11.43 +/- 1.92% at a concentrations of 68.00M and 7.88 +/- 1.21% and 16.96 +/- 4.24% at a concentration of 68.50M, respectively.
引用
收藏
页码：322 / 326
页数：5
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