Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

被引：17
|
作者：
Chen, Yan-Mei [1 ]
Li, Chen [1 ]
Zhang, Wen-Jing [1 ]
Shi, Yan [1 ]
Wen, Zi-Jie [1 ]
Chen, Qing-Xi [1 ]
Wang, Qin [1 ]
机构：
[1] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2019年 / 34卷 / 01期
基金：
美国国家科学基金会;
关键词：
Kojic acid derivatives; tyrosinase inhibition; antioxidant; CATECHOLASE ACTIVITY; SERUM-ALBUMIN; INHIBITION; ANTITYROSINASE; ANALOGS; BINDING;
D O I：
10.1080/14756366.2019.1609467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS(+) assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.
引用
收藏
页码：990 / 998
页数：9
相关论文
共 50 条
  • [41] Synthesis, structural elucidation, antioxidant, CT-DNA binding and molecular docking studies of novel chloroquinoline derivatives: Promising antioxidant and anti-diabetic agents
    Murugavel, S.
    Stephen, C. S. Jacob Prasanna
    Subashini, R.
    AnanthaKrishnan, Dhanabalan
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2017, 173 : 216 - 230
  • [42] Synthesis, Anti-acetylcholinesterase Evaluation, Molecular Docking and Molecular Dynamics Simulation of Novel Psoralen Derivatives
    Hasan, Aso Hameed
    Yusof, Faten Syahira Mohamed
    Kamarudin, Natasha Amira
    Murugesan, Sankaranarayanan
    Shakya, Sonam
    Jamalis, Joazaizulfazli
    CURRENT ORGANIC SYNTHESIS, 2024, 21 (01) : 61 - 77
  • [43] Imidazole derivatives as novel and potent antifungal agents: Synthesis, biological evaluation, molecular docking study, molecular dynamic simulation and ADME prediction
    Sadeghian, Sara
    Bekhradi, Fatemeh
    Mansouri, Fatemeh
    Razmi, Raziyeh
    Mansouri, Seyed Gholamhossein
    Poustforoosh, Alireza
    Khabnadideh, Soghra
    Zomorodian, Kamyar
    Zareshahrabadi, Zahra
    Rezaei, Zahra
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1302
  • [44] Synthesis, Molecular Docking and Dynamics Simulation Studies of New 7-oxycoumarin Derivatives as Potential Antioxidant Agents
    Latif, Nehad A. Abdel
    Batran, Rasha Z.
    Mohamed, Salwa F.
    Khedr, Mohammed A.
    Kobeasy, Mohamed I.
    Al-Shehri, Sara A. F.
    Awad, Hanem M.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2018, 18 (18) : 1572 - 1587
  • [45] 3D-QSAR study, docking molecular and simulation dynamic on series of benzimidazole derivatives as anti-cancer agents
    El Mchichi, L.
    Tabti, K.
    Kasmi, R.
    El-Mernissi, R.
    El Aissouq, A.
    En-nahli, F.
    Belhassan, A.
    Lakhlifi, T.
    Bouachrine, M.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2022, 99 (09)
  • [46] Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies
    Nazir, Yasir
    Saeed, Aamer
    Rafiq, Muhammad
    Afzal, Samina
    Ali, Anser
    Latif, Muhammad
    Zuegg, Johannes
    Hussein, Waleed M.
    Fercher, Christian
    Barnard, Ross T.
    Cooper, Matthew A.
    Blaskovich, Mark A. T.
    Ashraf, Zaman
    Ziora, Zyta M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (01)
  • [47] Novel piperazine substituted indole derivatives: Synthesis, anti-inflammatory and antioxidant activities and molecular docking
    Altuntas, Tunca Gul
    Baydar, Aziz
    Kilic-Kurt, Zuhal
    Acar, Cemre
    Yilmaz-Sarialtin, Sezen
    Coban, Tulay
    JOURNAL OF RESEARCH IN PHARMACY, 2020, 24 (03): : 350 - 360
  • [48] Synthesis and molecular docking study of novel alizarin derivatives containing phosphoryl amino acid moiety as potential antitumor agents
    Huang, Ri-zhen
    Jin, Le
    Yao, Gui-yang
    Dai, Wei-long
    Huang, Xiao-chao
    Liao, Zhi-Xin
    Wang, Heng-shan
    MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (10) : 2363 - 2374
  • [49] Synthesis and molecular docking study of novel alizarin derivatives containing phosphoryl amino acid moiety as potential antitumor agents
    Ri-zhen Huang
    Le Jin
    Gui-yang Yao
    Wei-long Dai
    Xiao-chao Huang
    Zhi-Xin Liao
    Heng-shan Wang
    Medicinal Chemistry Research, 2017, 26 : 2363 - 2374
  • [50] Design, synthesis, and molecular dynamics simulation studies of some novel kojic acid fused 2-amino-3-cyano-4H-pyran derivatives as tyrosinase inhibitors
    Najafi, Zahra
    Haramabadi, Maryam Zandi
    Chehardoli, Gholamabbas
    Ebadi, Ahmad
    Iraji, Aida
    BMC CHEMISTRY, 2024, 18 (01)
12345