Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

被引：17
|
作者：
Chen, Yan-Mei [1 ]
Li, Chen [1 ]
Zhang, Wen-Jing [1 ]
Shi, Yan [1 ]
Wen, Zi-Jie [1 ]
Chen, Qing-Xi [1 ]
Wang, Qin [1 ]
机构：
[1] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2019年 / 34卷 / 01期
基金：
美国国家科学基金会;
关键词：
Kojic acid derivatives; tyrosinase inhibition; antioxidant; CATECHOLASE ACTIVITY; SERUM-ALBUMIN; INHIBITION; ANTITYROSINASE; ANALOGS; BINDING;
D O I：
10.1080/14756366.2019.1609467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS(+) assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.
引用
收藏
页码：990 / 998
页数：9
相关论文
共 50 条
  • [31] Novel pyrano-triazolo-pyrimidine derivatives as anti- α-amylase agents: Synthesis, molecular docking investigations and computational analysis
    Hajlaoui, Amel
    Laajimi, Maha
    Znati, Mansour
    Ben Jannet, Hichem
    Romdhane, Anis
    JOURNAL OF MOLECULAR STRUCTURE, 2021, 1237
  • [32] Phytochemical analysis, bioactivity, and molecular docking studies of Myrtus communis L. seeds and fruit peel extracts demonstrating antioxidant and anti-tyrosinase properties
    Al-Najjar, Belal O.
    Elshibani, Fatma
    Sharkasi, Mohamed A.
    El Shintiri, Nouha
    El Naili, Esra
    Abdulsayid, Munira
    Abozayed, Roya S.
    Mohammed, Hamdoon A.
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [33] QSAR modeling, molecular docking, dynamic simulation and ADMET study of novel tetrahydronaphthalene derivatives as potent antitubercular agents
    Moulishankar, Anguraj
    Sundarrajan, T.
    BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES, 2023, 12 (01)
  • [34] QSAR modeling, molecular docking, dynamic simulation and ADMET study of novel tetrahydronaphthalene derivatives as potent antitubercular agents
    Anguraj Moulishankar
    T. Sundarrajan
    Beni-Suef University Journal of Basic and Applied Sciences, 12
  • [35] Design, synthesis, in silico ADME, DFT, molecular dynamics simulation, anti-tyrosinase, and antioxidant activity of some of the 3-hydroxypyridin-4-one hybrids in combination with acylhydrazone derivatives
    Fazel, Razieh
    Hassani, Bahareh
    Zare, Fateme
    Darzi, Habibollah Jokar
    Khoshneviszadeh, Mehdi
    Poustforoosh, Alireza
    Behrouz, Marzieh
    Sabet, Razieh
    Sadeghpour, Hossein
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 42 (18): : 9518 - 9528
  • [36] Biological Effects of Calceolarioside A as a Natural Compound: Anti-Ovarian Cancer, Anti-Tyrosinase, and Anti-HMG-CoA Reductase Potentials with Molecular Docking and Dynamics Simulation Studies
    Chen, Liqin
    Han, Dan
    Gu, Chunyan
    Huang, Wei
    MOLECULAR BIOTECHNOLOGY, 2025,
  • [37] Synthesis, In Silico Studies, Antimicrobial, Antioxidant Activities, Docking Simulation, and Computational Analysis of Novel Acrylamide Derivatives
    Bayrak, H.
    Fahim, A. M.
    Boyraci, G. M.
    Karahalil, F. Y.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (08) : 2044 - 2060
  • [38] N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study
    Youssef, Khairia M.
    Fawzy, Iten M.
    El-Subbagh, Hussein, I
    FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 4 (01) : 1 - 7
  • [39] Molecular docking, synthesis and biological screening of mefenamic acid derivatives as anti-inflammatory agents
    Savjani, Jignasa K.
    Mulamkattil, Suja
    Variya, Bhavesh
    Patel, Snehal
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 801 : 28 - 34
  • [40] Design, synthesis, biological evaluation, molecular docking, and dynamic simulation study of novel imidazo[2,1-b]thiazole derivatives as potent antioxidant agents
    Dincel, Efe Dogukan
    Hasbal-Celikok, Gozde
    Yilmaz-Ozden, Tugba
    Ulusoy-Guzeldemirci, Nuray
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1258
12345