Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

被引：17
|
作者：
Chen, Yan-Mei [1 ]
Li, Chen [1 ]
Zhang, Wen-Jing [1 ]
Shi, Yan [1 ]
Wen, Zi-Jie [1 ]
Chen, Qing-Xi [1 ]
Wang, Qin [1 ]
机构：
[1] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2019年 / 34卷 / 01期
基金：
美国国家科学基金会;
关键词：
Kojic acid derivatives; tyrosinase inhibition; antioxidant; CATECHOLASE ACTIVITY; SERUM-ALBUMIN; INHIBITION; ANTITYROSINASE; ANALOGS; BINDING;
D O I：
10.1080/14756366.2019.1609467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS(+) assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.
引用
收藏
页码：990 / 998
页数：9
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