An efficient and regioselective one-pot multi-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in Water

被引：29
|
作者：
Majumder, Swarup [1 ]
Borah, Pallabi [1 ]
Bhuyan, Pulak J. [1 ]
机构：
[1] CSIR North East Inst Sci &i Technol, Div Med Chem, Jorhat 785006, Assam, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 06期
关键词：
Pyrimido[4,5-d]pyrimidine; Multicomponent reaction; Isothiocyanate; N; N-Dimethyl 6-amino uracil; p-Toluenesulfonic acid (p-TSA); ORGANIC-REACTIONS; SOLVENT; GREEN;
D O I：
10.1016/j.tetlet.2013.12.095
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrimido[4,5-d]pyrimidine derivatives 4 have been prepared in an efficient and regioselective manner in water via multi-component reaction of isothiocyanate 1, aromatic aldehyde 2, N,N-dimethyl-6-amino uracil 3 in the presence of p-toluenesulfonic acid (p-TSA) as a Lewis acid catalyst. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1168 / 1170
页数：3
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