Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

被引：7

作者：

Pedgaonkar, Yogesh Y. ^{[1
]}

Degani, Mariam S. ^{[1
]}

Iyer, Radhakrishnan P. ^{[2
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

[2] Spring Bank Pharmaceut Inc, Milford, MA 01757 USA

来源：

MOLECULAR DIVERSITY | 2011年 / 15卷 / 01期

关键词：

Multicomponent reaction; Carbonylation; Cyclization; 5-cyanouracil; Triphosgene; MCR; OLIGONUCLEOTIDES; ANTI-HIV-1;

D O I：

10.1007/s11030-010-9266-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.

引用

页码：263 / 267

页数：5

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