A study on the interaction between ibuprofen and bilayer lipid membrane

被引：62
|
作者：
Du, Liangwei
Liu, Xiaohua
Huang, Weimin
Wang, Erkang [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
ELECTROCHIMICA ACTA | 2006年 / 51卷 / 26期
基金：
中国国家自然科学基金;
关键词：
ibuprofen; interaction; bilayer lipid membrane; UV-vis spectroscopy; cyclic voltammetry; AC impedance spectroscopy; biphasic behavior;
D O I：
10.1016/j.electacta.2006.03.009
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Ibuprofen is a well-known nonsteroidal anti-inflammatory drug, which can interact with lipid membranes. In this paper, the interaction of ibuprofen with bilayer lipid membrane was studied by UV-vis spectroscopy, cyclic voltammetry and AC impedance spectroscopy. UV-vis spectroscopy data indicated directly that ibuprofen could interact with lipid vesicles. In electrochemical experiments, ibuprofen displayed a biphasic behavior on bilayer lipid membrane supported on a glassy carbon electrode. It could stabilize the lipid membrane in low concentration, while it induced defects formation, even removed off bilayer lipid membrane from the surface of the electrode with increasing concentration. The mechanism about the interaction between ibuprofen and supported bilayer lipid membrane was discussed. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：5754 / 5760
页数：7
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