A study on the interaction between ibuprofen and bilayer lipid membrane

被引：62
|
作者：
Du, Liangwei
Liu, Xiaohua
Huang, Weimin
Wang, Erkang [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
ELECTROCHIMICA ACTA | 2006年 / 51卷 / 26期
基金：
中国国家自然科学基金;
关键词：
ibuprofen; interaction; bilayer lipid membrane; UV-vis spectroscopy; cyclic voltammetry; AC impedance spectroscopy; biphasic behavior;
D O I：
10.1016/j.electacta.2006.03.009
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Ibuprofen is a well-known nonsteroidal anti-inflammatory drug, which can interact with lipid membranes. In this paper, the interaction of ibuprofen with bilayer lipid membrane was studied by UV-vis spectroscopy, cyclic voltammetry and AC impedance spectroscopy. UV-vis spectroscopy data indicated directly that ibuprofen could interact with lipid vesicles. In electrochemical experiments, ibuprofen displayed a biphasic behavior on bilayer lipid membrane supported on a glassy carbon electrode. It could stabilize the lipid membrane in low concentration, while it induced defects formation, even removed off bilayer lipid membrane from the surface of the electrode with increasing concentration. The mechanism about the interaction between ibuprofen and supported bilayer lipid membrane was discussed. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：5754 / 5760
页数：7
相关论文
共 50 条
  • [21] Undulation instability in a bilayer lipid membrane due to electric field interaction with lipid dipoles
    Bingham, Richard J.
    Olmsted, Peter D.
    Smye, Stephen W.
    [J]. PHYSICAL REVIEW E, 2010, 81 (05)
  • [22] Assessing the interaction between the N-terminal region of the membrane protein magnesium transporter A and a lipid bilayer
    Skog, Amanda Eriksson
    Jones, Nykola C.
    Månsson, Linda K.
    Morth, Jens Preben
    Vrønning Hoffmann, Søren
    Gerelli, Yuri
    Skepö, Marie
    [J]. Journal of Colloid and Interface Science, 2025, 683 : 663 - 674
  • [23] Interaction between a rodlike inclusion and a supported bilayer membrane
    Zhang, Qiyi
    Ma, Yuqiang
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2006, 125 (16):
  • [24] Insertion Study of Adriamycin and Quelamycin into Bilayer Lipid Membrane
    Du, Liangwei
    Zeng, Sumei
    Cai, Zhuo
    Wang, Yanhui
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (11) : 4944 - 4948
  • [25] Lipid Bilayer Strengthens the Side Chain Interaction Network of a Membrane Protein
    Nazaar, Fathima Shaima Muhammed
    Guo, Ruiqiong
    Rhee, Seung-Hyo
    Kang, Seung-gu
    Hong, Heedeok
    [J]. BIOPHYSICAL JOURNAL, 2021, 120 (03) : 134A - 134A
  • [26] Interaction of whole influenza virions with planar bilayer lipid membrane.
    Simonenko, EY
    Butylin, AA
    [J]. BIOPHYSICAL JOURNAL, 2000, 78 (01) : 57A - 57A
  • [27] Vesicle Fusion with Artificial Bilayer Lipid Membrane Induced by Electrostatic Interaction
    Oshima, Azusa
    Sumitomo, Koji
    [J]. BUNSEKI KAGAKU, 2019, 68 (01) : 23 - 32
  • [28] INTERACTION OF GRAMICIDIN-S ANALOGS WITH LIPID BILAYER-MEMBRANE
    YAGI, Y
    KIMURA, S
    IMANISHI, Y
    [J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 36 (01): : 18 - 25
  • [29] KEYHOLE LIMPET HEMOCYANIN (KLH)-LIPID BILAYER MEMBRANE (BLM) INTERACTION
    PANT, HC
    CONRAN, P
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 1972, 8 (04): : 357 - +
  • [30] Probing into the interaction of β-amyloid peptides with bilayer lipid membrane by electrochemical techniques
    Zhao, Jing
    Gao, Tao
    Yan, Yalin
    Chen, Guifang
    Li, Genxi
    [J]. ELECTROCHEMISTRY COMMUNICATIONS, 2013, 30 : 26 - 28
12345