Voltammetric Behaviour of 7-Methylguanine Using Screen-printed Graphite Electrodes: towards a Guanine Methylation Electrochemical Sensor

被引：14
|
作者：
Brotons, Ariadna [1 ]
Sanjuan, Ignacio [1 ]
Banks, Craig E. [3 ]
Jose Vidal-Iglesias, Francisco [1 ]
Solla-Gullon, Jose [1 ]
Iniesta, Jesus [1 ,2 ]
机构：
[1] Univ Alicante, Inst Electrochem, Alicante 03690, Spain
[2] Univ Alicante, Dept Phys Chem, Alicante 03690, Spain
[3] Manchester Metropolitan Univ, Sch Chem & Environm, Fac Sci & Engn, Div Chem & Environm Sci, Manchester M1 5GD, Lancs, England
来源：
ELECTROANALYSIS | 2015年 / 27卷 / 12期
关键词：
Screen printed graphite electrode; guanine; 7-methylguanine; adenine; DNA methylation; LIQUID-CHROMATOGRAPHY; URINARY-EXCRETION; DNA-ADDUCTS; PROTEIN ADDUCTS; NUCLEIC-ACIDS; OXIDATION; O-6-METHYLGUANINE; PURINES; QUANTITATION; TISSUES;
D O I：
10.1002/elan.201500263
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The determination of 7-methylguanine (7mG) is an interesting analytical target since its quantification can be correlated with the methylation of cytosine which is one of the most relevant epigenetic modification of DNA. In this work, screen-printed graphite electrodes were used to study the electrochemical characterization of 7mG by cyclic and square wave voltammetry. 7mG concentration and pH were examined, as well as the repeatability of the measurements. The electrochemical response of 7mG in the presence of guanine and adenine was also investigated. Results aim to the future development of an electrochemical sensor for the methylation degree in DNA.
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页码：2766 / 2772
页数：7
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