In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

被引：27
|
作者：
Cota, Jason [1 ]
Carden, Michael [1 ]
Graybill, John R. [1 ]
Najvar, Laura K. [1 ]
Burgess, David S. [1 ]
Wiederhold, Nathan P. [1 ]
机构：
[1] UTHSCSA, Austin Coll Pharm, Clin Pharm, San Antonio, TX 78229 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期
关键词：
D O I：
10.1128/AAC.00538-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.
引用
收藏
页码：3926 / 3928
页数：3
相关论文
共 50 条
  • [1] Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility
    Brzankalski, Gabriela E.
    Najvar, Laura K.
    Wiederhold, Nathan P.
    Bocanegra, Rosie
    Fothergill, Annette W.
    Rinaldi, Michael G.
    Pattterson, Thomas F.
    Graybill, John R.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) : 1094 - 1100
  • [2] In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata
    Oliveira, ER
    Fothergill, AW
    Kirkpatrick, WR
    Coco, BJ
    Patterson, TF
    Redding, SW
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) : 3544 - 3545
  • [3] In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera
    Wiederhold, Nathan P.
    Najvar, Laura K.
    Bocanegra, Rosie
    Molina, Destiny
    Livo, Marcos
    Graybill, John R.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (05) : 1616 - 1620
  • [4] Anidulafungin versus Caspofungin in a Mouse Model of Candidiasis Caused by Anidulafungin-Susceptible Candida parapsilosis Isolates with Different Degrees of Caspofungin Susceptibility
    Dimopoulou, Dimitra
    Hamilos, Georgios
    Tzardi, Maria
    Lewis, Russell E.
    Samonis, George
    Kontoyiannis, Dimitrios P.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (01) : 229 - 236
  • [5] Comparative In Vitro Susceptibility of Clinical Isolates of Candida parapsilosis Complex and Other Candida Species to Caspofungin and Anidulafungin by Etest
    Khan, Z.
    Ahmad, S.
    Joseph, L.
    Chandy, R.
    Theyyathel, A.
    JOURNAL OF CHEMOTHERAPY, 2011, 23 (02) : 97 - 101
  • [6] Differential In Vivo Activities of Anidulafungin, Caspofungin, and Micafungin against Candida glabrata Isolates with and without FKS Resistance Mutations
    Arendrup, Maiken Cavling
    Perlin, David S.
    Jensen, Rasmus Hare
    Howard, Susan Julie
    Goodwin, Joanne
    Hope, William
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) : 2435 - 2442
  • [7] Detailed comparison of Candida albicans and Candida glabrata biofilms under different conditions and their susceptibility to caspofungin and anidulafungin
    Kucharikova, Sona
    Tournu, Helene
    Lagrou, Katrien
    Van Dijck, Patrick
    Bujdakova, Helena
    JOURNAL OF MEDICAL MICROBIOLOGY, 2011, 60 (09) : 1261 - 1269
  • [8] Assessment of the In Vitro Kinetic Activity of Caspofungin against Candida glabrata
    Nagappan, V.
    Boikov, D.
    Vazquez, J. A.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (01) : 522 - 525
  • [9] Killing kinetics of caspofungin and anidulafungin against Candida krusei
    Canton, E.
    Peman, J.
    Viudes, A.
    Espinel-Ingroff, A.
    Valentin, A.
    Bosch, M.
    Gobernado, M.
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 : S562 - S562
  • [10] In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin:: Six years of global surveillance
    Pfaller, M. A.
    Boyken, L.
    Hollis, R. J.
    Kroeger, J.
    Messer, S. A.
    Tendolkar, S.
    Diekema, D. J.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (01) : 150 - 156
12345