In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

被引：27
|
作者：
Cota, Jason [1 ]
Carden, Michael [1 ]
Graybill, John R. [1 ]
Najvar, Laura K. [1 ]
Burgess, David S. [1 ]
Wiederhold, Nathan P. [1 ]
机构：
[1] UTHSCSA, Austin Coll Pharm, Clin Pharm, San Antonio, TX 78229 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期
关键词：
D O I：
10.1128/AAC.00538-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.
引用
收藏
页码：3926 / 3928
页数：3
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