Stimulatory effects of centrally injected nitric oxide donors on gastric acid secretion in anesthetized rats

被引：2
|
作者：
Tsuchiya, S [1 ]
Horie, S [1 ]
Watanabe, K [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Chiba 2638522, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 89卷 / 02期
关键词：
nitric oxide donor; central nervous system; stomach; acid secretion;
D O I：
10.1254/jjp.89.126
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of centrally injected nitric oxide (NO) donors on gastric acid secretion were investigated in continuously perfused stomach of anesthetized rats. The lateral cerebroventricular (LV) injection of NOC5 (30 - 100 mug) and NOC12 (10 - 100 mug) dose-dependently stimulated gastric acid secretion. The LV injection of NOC18 (30 mug) also stimulated gastric acid secretion. The other type of NO donor, sodium nitroprusside (3 - 30 mug, LV), also dose-dependently stimulated gastric acid secretion. The effect of NOC5 at 100 mug was blocked by carboxy-PTIO, an NO scavenger, and by cervical vagotomy. Furthermore, NOC12 (30, 100 mug) dose-dependently stimulated gastric acid secretion in pylorus-ligated conscious rats. These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation.
引用
收藏
页码：126 / 132
页数：7
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