NITRIC-OXIDE DONORS PREFERENTIALLY INHIBIT NEURONALLY MEDIATED RAT GASTRIC-ACID SECRETION

被引：33
|
作者：
BARRACHINA, D
CALATAYUD, S
ESPLUGUES, J
WHITTLE, BJR
MONCADA, S
ESPLUGUES, JV
机构：
[1] UNIV VALENCIA,FAC MED,DEPT FARMACOL,E-46010 VALENCIA,SPAIN
[2] WELLCOME RES LABS,DEPT PHARMACOL,BECKENHAM BR3 3BS,KENT,ENGLAND
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期
关键词：
GASTRIC ACID; NITRIC OXIDE (NO); GASTRIC DISTENSION; 2-DEOXY-D-GLUCOSE; HISTAMINE; PENTAGASTRIN; BRAIN-GUT AXIS;
D O I：
10.1016/0014-2999(94)90044-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Continuous i.v. infusion of the nitric oxide (NO) donors, S-nitroso-glutathione (10-50 mu g kg(-1) min(-1)) and S-nitroso-N-acetyl-penicillamine (10 mu g kg(-1) min(-1)) inhibited neuronally mediated gastric acid secretion, as induced by gastric distension (20 cm water) or i.v. bolus administration of 2-deoxy-D-glucose (150 mg kg(-1)) in the anaesthetized rat. By contrast, gastric acid responses to i.v. infusion of submaximal doses of pentagastrin (8 mu g kg(-1) h(-1)) or histamine (1 mg kg(-1) h(-1)) were not influenced by these NO donors. These findings suggest that NO does not directly influence acid secretion in vivo but could play an inhibitory modulator role in neuronally mediated acid responses.
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页码：181 / 183
页数：3
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