The Escherichia coli Mismatch Repair Protein MutL Recruits the Vsr and MutH Endonucleases in Response to DNA Damage

被引：10

作者：

Polosina, Yaroslava Y. ^{[1
]}

Mui, Justin ^{[1
]}

Pitsikas, Photini ^{[1
]}

Cupples, Claire G. ^{[1
]}

机构：

[1] Univ Victoria, Dept Biochem & Microbiol, STN CSC, Victoria, BC V8N 3P2, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 12期

关键词：

SHORT-PATCH REPAIR; FUNCTIONAL INTERACTIONS; OVEREXPRESSION; TRANSVERSIONS; MUTATIONS; ABUNDANCE; SYSTEM; GENOME;

D O I：

10.1128/JB.00066-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activities of the Vsr and MutH endonucleases of Escherichia coli are stimulated by MutL. The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage.

引用

页码：4041 / 4043

页数：3

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