The Escherichia coli Mismatch Repair Protein MutL Recruits the Vsr and MutH Endonucleases in Response to DNA Damage

被引：10
|
作者：
Polosina, Yaroslava Y. [1 ]
Mui, Justin [1 ]
Pitsikas, Photini [1 ]
Cupples, Claire G. [1 ]
机构：
[1] Univ Victoria, Dept Biochem & Microbiol, STN CSC, Victoria, BC V8N 3P2, Canada
来源：
JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 12期
关键词：
SHORT-PATCH REPAIR; FUNCTIONAL INTERACTIONS; OVEREXPRESSION; TRANSVERSIONS; MUTATIONS; ABUNDANCE; SYSTEM; GENOME;
D O I：
10.1128/JB.00066-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of the Vsr and MutH endonucleases of Escherichia coli are stimulated by MutL. The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage.
引用
收藏
页码：4041 / 4043
页数：3
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