Anti-HIV protease triterpenoids from the acid hydrolysate of Panax ginseng

被引：32
|
作者：
Wei, Ying [1 ,2 ]
Ma, Chao-Mei [1 ]
Hattori, Masao [1 ]
机构：
[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan
[2] Guiyang Coll Tradit Chinese Med, Dept Pharm, Guiyang 550002, Guizhou, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2009年 / 2卷 / 02期
关键词：
Panax ginseng; Araliaceae; Triterpenoid; (20R)-20,25-Epoxy-dammaran-2-en-6 alpha,12 beta-diol; (20R)-20,25-Epoxy-3-methyl-28-nordammaran-2-en-6 alpha,12 beta-diol; Isodehydroprotopanaxatriol; HIV-1 protease inhibitor; SAPONINS;
D O I：
10.1016/j.phytol.2008.12.001
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three artificial triterpenoids, (20R)-20,25-epoxy-dammaran-2-en-6 alpha,12 beta-diol (1), (2OR)-20,25-epoxy-3-methyl-28-nordammaran-2-en-6 alpha,12 beta-diol (2) and isodehydroprotopanaxatriol (3), were isolated from an acidic hydrolysate of Panax ginseng C.A. Meyer, along with three known triterpenes, (20R)-panaxadiol (4),(20R)-panaxatriol (5) and oleanolic acid (6). Compounds 1-3 and 6 showed inhibitory activity against HIV-1 protease with IC50 of 10.5, 10.3, 12.3 and 6.3 mu M, respectively. The results indicated that acid treatment of Ginseng extract could produce diverse structures with interesting bioactivity. (C) 2008 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：63 / 66
页数：4
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