Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp intermedia

被引：50
|
作者：
Wei, Ying [1 ]
Ma, Chao-Mei [1 ]
Chen, De-Yuan [2 ]
Hattori, Masao [1 ]
机构：
[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan
[2] Guiyang Coll Tradit Chinese Med, Dept Pharm, Guiyang 550002, Peoples R China
来源：
PHYTOCHEMISTRY | 2008年 / 69卷 / 09期
关键词：
Stauntonia obovatifoliola; Lardizabalaceae; triterpenoid; 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid; 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid and 16 beta-hydroxylupane-1,20(29)-dien-3-one; HIV-1 protease inhibitors;
D O I：
10.1016/j.phytochem.2008.03.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three triterpenoids, 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (1), 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (2) and 16 beta-hydroxylupane-1,20(29)-dien-3-one (3), along with eleven known triterpenes were isolated from stems of Stauntonia obovatifoliola Hayata subsp. intermedia (Y.C. Wu) T. Chen. Their structures were determined by analysis of HR-EI/FAB-MS and 1D and 2D NMR spectroscopic data and comparison with those in the literature. Ten of the compounds showed inhibitory activity against HIV-1 protease. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1875 / 1879
页数：5
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