Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp intermedia

被引：50

作者：

Wei, Ying ^{[1
]}

Ma, Chao-Mei ^{[1
]}

Chen, De-Yuan ^{[2
]}

Hattori, Masao ^{[1
]}

机构：

[1] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Guiyang Coll Tradit Chinese Med, Dept Pharm, Guiyang 550002, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 09期

关键词：

Stauntonia obovatifoliola; Lardizabalaceae; triterpenoid; 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid; 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid and 16 beta-hydroxylupane-1,20(29)-dien-3-one; HIV-1 protease inhibitors;

D O I：

10.1016/j.phytochem.2008.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three triterpenoids, 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (1), 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (2) and 16 beta-hydroxylupane-1,20(29)-dien-3-one (3), along with eleven known triterpenes were isolated from stems of Stauntonia obovatifoliola Hayata subsp. intermedia (Y.C. Wu) T. Chen. Their structures were determined by analysis of HR-EI/FAB-MS and 1D and 2D NMR spectroscopic data and comparison with those in the literature. Ten of the compounds showed inhibitory activity against HIV-1 protease. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1875 / 1879

页数：5

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