1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide

被引：7
|
作者：
Tamazyan, R
Karapetyan, H
Martirosyan, A
Hovhannesyan, V
Gasparyan, S
机构：
[1] Natl Acad Sci RA, Mol Struct Res Ctr, Yerevan 375014, Armenia
[2] Natl Acad Sci RA, Inst Fine Organ Chem, Yerevan 375014, Armenia
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2002年 / 58卷
关键词：
D O I：
10.1107/S0108270102008636
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The structures of two potential anti-human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTI), namely 1-(2-chlorobenzoyl)-2-phenylpyrrolidine-2-carboxamide, C18H17ClN2O2, and 1-(2-furoyl)2-phenylpyrrolidine-2-carboxamide, C16H16N2O3, have been investigated by X-ray diffraction and the butterfly-like conformation established in each case. The pyrrolidine ring has the same half-chair conformation in both structures.
引用
收藏
页码：o386 / o388
页数：3
相关论文
共 50 条
  • [31] SYNTHESIS OF BRIDGEHEAD DERIVATIVES .2. PREPARATION OF 1-SUBSTITUTED BICYCLO[2.2.1]HEPTANES
    MARTINEZ, AG
    VILAR, ET
    LOPEZ, JC
    ALONSO, JM
    HANACK, M
    SUBRAMANIAN, LR
    SYNTHESIS-STUTTGART, 1991, (05): : 353 - 354
  • [32] Short syntheses of 1-substituted dibenzothiophene derivatives
    Welsh, Erin N.
    Robertson, Katherine N.
    Speed, Alexander W. H.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 19 (09) : 2000 - 2007
  • [33] DIPOLE MOMENTS OF 1-SUBSTITUTED ADAMANTANE DERIVATIVES
    MAZHEIKA, IB
    YANKOVSK.IS
    POLIS, YY
    ZHURNAL OBSHCHEI KHIMII, 1971, 41 (07): : 1633 - &
  • [34] SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF DIHYDROPYRIMIDINONE AND QUINAZOLINONE
    MICKYAVICHIUS, VY
    BALTRUSHIS, RS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1992, (10): : 1391 - 1394
  • [35] REACTION OF 1-SUBSTITUTED SEMICARBAZIDE DERIVATIVES WITH BENZALDEHYDE
    NOVACEK, A
    GUT, J
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1975, 40 (11) : 3512 - 3518
  • [36] SYNTHESIS OF SOME DERIVATIVES OF 1-SUBSTITUTED TETRAHYDROISOQUINOLINES
    LEVI, M
    IVANOV, C
    DRYANSKA, M
    PAVLOVA, A
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1971, 5 (02): : 33 - &
  • [37] Synthesis of 1-substituted derivatives of 2,5-diphenylsilacyclopent-3-enes and 2,5-diphenylsilacyclopentanes
    Nagao, Y
    Sakamoto, S
    Miyakawa, K
    Abe, Y
    Jung, ME
    NIPPON KAGAKU KAISHI, 2000, (06) : 411 - 417
  • [38] THE USE OF HPLC IN THE SEPARATION OF CHIRAL 1-SUBSTITUTED, 2-SUBSTITUTED AND 1-SUBSTITUTED, 3-SUBSTITUTED CYCLOPENTADIENYL ORGANOMETALLIC COMPLEXES
    BITTERWOLF, TE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 203 : 409 - INOR
  • [39] Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents
    Micale, N
    De Sarro, G
    Ferreri, G
    Zappalá, M
    Grasso, S
    Puia, G
    De Micheli, C
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (13) : 3703 - 3709
  • [40] SYNTHESIS OF 1-SUBSTITUTED AND 2-SUBSTITUTED INDAZOLES AS ANTHELMINTIC AGENTS
    KINGSBURY, WD
    GYURIK, RJ
    THEODORIDES, VJ
    PARISH, RC
    GALLAGHER, G
    JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (06) : 839 - 840
12345