Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents

被引：9
|
作者：
Micale, N
De Sarro, G
Ferreri, G
Zappalá, M
Grasso, S
Puia, G
De Micheli, C
机构：
[1] Univ Milan, Ist Chim Farmaceut, I-20121 Milan, Italy
[2] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy
[3] Univ Catanzaro, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy
[4] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 13期
关键词：
D O I：
10.1016/j.bmc.2004.04.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structurally related to model compound 5 (2-[(4-aminophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester), were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3703 / 3709
页数：7
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