Novel coumarin derivatives: Synthesis, anti-breast cancer activity and docking study

被引：8
|
作者：
Han, Hao [1 ]
Zhang, Zhi-Fang [2 ]
Zhang, Jun-Fei [3 ]
Zhang, Bin [1 ,3 ]
机构：
[1] Inner Mongolia Univ Nationlities, Tongliao, Inner Mongolia, Peoples R China
[2] Tongliao City Hosp, Dept Nursing, Tongliao, Inner Mongolia, Peoples R China
[3] Inner Mongolia Univ Nationlities, Affiliated Hosp 1, Tongliao, Inner Mongolia, Peoples R China
来源：
MAIN GROUP CHEMISTRY | 2019年 / 18卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Coumarin; X-ray crystallography; cancer cell; molecular docking; DIHYDROPYRAN DERIVATIVES; BISCOUMARIN;
D O I：
10.3233/MGC-180682
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of coumarin derivatives (1-9) were synthesized with the aim of using them as anticancer agents in clinical trials, and their structures were characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. Their anticancer activity against four human breast cancer cells including MDA-MB-231, MDA-MB-468, Hst578 and HCC1937 were evaluated in vitro using the MTT assay, and the results showed that compounds 1-3 had more efficient anticancer activity against the four cancer cells, however compounds 4-9 did not show any inhibition. Furthermore, molecular docking studies supported the biological assay data and suggested that compounds 1-3 may be potential anticancer agents.
引用
收藏
页码：71 / 79
页数：9
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