Novel coumarin derivatives: Synthesis, anti-breast cancer activity and docking study

被引：8

作者：

Han, Hao ^{[1
]}

Zhang, Zhi-Fang ^{[2
]}

Zhang, Jun-Fei ^{[3
]}

Zhang, Bin ^{[1
,3
]}

机构：

[1] Inner Mongolia Univ Nationlities, Tongliao, Inner Mongolia, Peoples R China

[2] Tongliao City Hosp, Dept Nursing, Tongliao, Inner Mongolia, Peoples R China

[3] Inner Mongolia Univ Nationlities, Affiliated Hosp 1, Tongliao, Inner Mongolia, Peoples R China

来源：

MAIN GROUP CHEMISTRY | 2019年 / 18卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Coumarin; X-ray crystallography; cancer cell; molecular docking; DIHYDROPYRAN DERIVATIVES; BISCOUMARIN;

D O I：

10.3233/MGC-180682

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of coumarin derivatives (1-9) were synthesized with the aim of using them as anticancer agents in clinical trials, and their structures were characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. Their anticancer activity against four human breast cancer cells including MDA-MB-231, MDA-MB-468, Hst578 and HCC1937 were evaluated in vitro using the MTT assay, and the results showed that compounds 1-3 had more efficient anticancer activity against the four cancer cells, however compounds 4-9 did not show any inhibition. Furthermore, molecular docking studies supported the biological assay data and suggested that compounds 1-3 may be potential anticancer agents.

引用

页码：71 / 79

页数：9

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