New roles for DNA topoisomerase I

被引：1
|
作者：
Pourquier, P [1 ]
机构：
[1] Inst Bergonie, Lab Pharm, F-33076 Bordeaux, France
来源：
M S-MEDECINE SCIENCES | 2002年 / 18卷 / 10期
关键词：
D O I：
10.1051/medsci/20021810975
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
DNA topoisomerase I is an nuclear enzyme involved in multiple DNA transactions such as replication, transcription and chromosome condensation. Besides its activity of DNA relaxation, that is essential for the removal of torsional constraints associated with these processes, topoisomerase I may have other functions related to its kinase activity, its similarity with DNA recombinases, and its ability to be trapped by various DNA modifications. In this review, recent findings on the poisoning of topoisomerase I by a broad range of DNA lesions are discussed in the context of a possible role of the enzyme in DNA damage signalling to the cell death machinery.
引用
收藏
页码：975 / 981
页数：7
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