2-cyanoacetamide in the synthesis of heterocyclic compounds: Synthesis of new polysubstituted pyrazole, pyridine and pyrimidine derivatives

被引：14
|
作者：
El-Rady, EA [1 ]
Khalil, MA [1 ]
机构：
[1] S Valley Univ, Fac Sci, Dept Chem, Aswan, Egypt
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2004年 / 51卷 / 04期
关键词：
phenylmethylenecyanoacetamide; pyrazole; pyridine and pyrimidine;
D O I：
10.1002/jccs.200400118
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Phenylmethylenecyanoacetamide (1) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one-pot reaction step. Hydrazine hydrate (2a,b), cyanoacetamide (6a), cyanothioacetamide (6b), cyanoacetic acid hydrazide (6c), thiosemicarbazide (10), urea (14a), thiourea (14b) and 2-phenylenediamine (24) were selected as amine nucleophile reagents.
引用
收藏
页码：779 / 784
页数：6
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