2-cyanoacetamide in the synthesis of heterocyclic compounds: Synthesis of new polysubstituted pyrazole, pyridine and pyrimidine derivatives

被引：14

作者：

El-Rady, EA ^{[1
]}

Khalil, MA ^{[1
]}

机构：

[1] S Valley Univ, Fac Sci, Dept Chem, Aswan, Egypt

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2004年 / 51卷 / 04期

关键词：

phenylmethylenecyanoacetamide; pyrazole; pyridine and pyrimidine;

D O I：

10.1002/jccs.200400118

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phenylmethylenecyanoacetamide (1) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one-pot reaction step. Hydrazine hydrate (2a,b), cyanoacetamide (6a), cyanothioacetamide (6b), cyanoacetic acid hydrazide (6c), thiosemicarbazide (10), urea (14a), thiourea (14b) and 2-phenylenediamine (24) were selected as amine nucleophile reagents.

引用

页码：779 / 784

页数：6

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