Spirostanols from the roots and rhizomes of Trillium tschonoskii

被引：9
|
作者：
Meng, Chun-Wang [1 ,2 ]
Peng, Cheng [1 ,2 ]
Zhou, Qin-mei [1 ,2 ]
Yang, Huai [1 ,2 ]
Guo, Li [1 ,2 ]
Xiong, Liang [1 ,2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2015年 / 14卷
关键词：
Trillium tschonoskii; Liliaceae; Spirostanols; 18-Norspirostanols; Cytotoxic activity; PARIS SAPONIN VII; UNDERGROUND PARTS; STEROIDAL SAPONINS; DERIVATIVES; GLYCOSIDES;
D O I：
10.1016/j.phytol.2015.09.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two novel spirostanols, (23S, 24R, 25S)-18-norspirost-1,4,13-triene-21,23,24-triol-3,15-dione (1) and (23S, 24S, 25S)-spirost-5-ene1 beta,3 beta,21,23,24-pentaol (2), a new natural product (3), and two known analogues (4 and 5) were isolated from the ethyl acetate-soluble portion of the ethanolic extract of Trillium tschonoskii Maxim. Their structures were elucidated by extensive spectroscopic analyses, and their cytotoxic activities on four kinds of human tumor cells were studied in vitro. Compound 4 showed significant cytotoxic activity against MCF-7 and A549 with IC50 values of 6.16 +/- 2.21 and 28.5 +/- 11.5 mu M, respectively, while 5 exhibited selective cytotoxicity against A549 with an IC50 value of 13.0 +/- 4.51 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：134 / 137
页数：4
相关论文
共 50 条
  • [41] Steroidal Constituents from Roots and Rhizomes of Smilacina japonica
    Cui, Yuwen
    Yang, Xinjie
    Zhang, Dongdong
    Li, Yuze
    Zhang, Li
    Song, Bei
    Yue, Zhenggang
    Song, Xiaomei
    Tang, Haifeng
    MOLECULES, 2018, 23 (04):
  • [42] The Rhizome of Trillium tschonoskii Maxim. Extract Induces Apoptosis in Human Lung Cancer Cells
    Huang, Wenfeng
    Zou, Kun
    Xiong, Bin
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2011, 66 (9-10): : 477 - 484
  • [43] Isoprenylated flavonoids from the roots and rhizomes of Sophora tonkinensis
    Ding, PL
    Chen, DF
    HELVETICA CHIMICA ACTA, 2006, 89 (01) : 103 - 110
  • [44] Arylsulfonamides From the Roots and Rhizomes of Tupistra chinensis Baker
    Xu, Yue
    Liang, Xiaofei
    Li, Yuze
    Liang, Zhuofei
    Huang, Wenli
    Zhang, Huawei
    Jiang, Yi
    Cui, Jiucheng
    Song, Xiaomei
    NATURAL PRODUCT COMMUNICATIONS, 2020, 15 (04)
  • [45] Glycosidic constituents from the roots and rhizomes of Melicope pteleifolia
    Zhang, Yang
    Yang, Li-Jun
    Jiang, Kun
    Tan, Chang-Heng
    Tan, Jun-Jie
    Yang, Pei-Ming
    Zhu, Da-Yuan
    CARBOHYDRATE RESEARCH, 2012, 361 : 114 - 119
  • [46] Steroidal saponins from the rhizomes and roots of Smilax scobinicaulis
    Zhang, Cun-Li
    Gao, Jin-Ming
    Zhu, Wei
    PHYTOCHEMISTRY LETTERS, 2012, 5 (01) : 49 - 52
  • [47] Steroidal components from the roots and rhizomes of Helleborus thibetanus
    Li, Yuze
    Huang, Wenli
    Zhang, Huawei
    Jiang, Yi
    Deng, Chong
    Wang, Wei
    Liu, Jianli
    Song, Xiaomei
    Zhang, Dongdong
    PHYTOCHEMISTRY LETTERS, 2022, 50 : 31 - 35
  • [48] Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis
    Li, Yuze
    Wang, Xin
    He, Hao
    Zhang, Dongdong
    Jiang, Yi
    Yang, Xinjie
    Wang, Fei
    Tang, Zhishu
    Song, Xiaomei
    Yue, Zhenggang
    MOLECULES, 2015, 20 (08) : 13659 - 13669
  • [49] Mechanisms of reproductive isolation of interspecific hybridization between Trillium camschatcense and T.tschonoskii (Melanthiaceae)
    Ishizaki, Satomi
    Abe, Tamayo
    Ohara, Masashi
    PLANT SPECIES BIOLOGY, 2013, 28 (03) : 204 - 214
  • [50] Main Components of Polyphenols of Trillium tschonoskii Maxim. and Changes under Different Se Concentrations
    Shurui TENG
    Tianjie AO
    Qiang YANG
    Lujing LIAO
    Nian JIANG
    Xiaojiang ZHENG
    Medicinal Plant, 2017, (03) : 5 - 9
12345