Spirostanols from the roots and rhizomes of Trillium tschonoskii

被引：9

作者：

Meng, Chun-Wang ^{[1
,2
]}

Peng, Cheng ^{[1
,2
]}

Zhou, Qin-mei ^{[1
,2
]}

Yang, Huai ^{[1
,2
]}

Guo, Li ^{[1
,2
]}

Xiong, Liang ^{[1
,2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 14卷

关键词：

Trillium tschonoskii; Liliaceae; Spirostanols; 18-Norspirostanols; Cytotoxic activity; PARIS SAPONIN VII; UNDERGROUND PARTS; STEROIDAL SAPONINS; DERIVATIVES; GLYCOSIDES;

D O I：

10.1016/j.phytol.2015.09.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel spirostanols, (23S, 24R, 25S)-18-norspirost-1,4,13-triene-21,23,24-triol-3,15-dione (1) and (23S, 24S, 25S)-spirost-5-ene1 beta,3 beta,21,23,24-pentaol (2), a new natural product (3), and two known analogues (4 and 5) were isolated from the ethyl acetate-soluble portion of the ethanolic extract of Trillium tschonoskii Maxim. Their structures were elucidated by extensive spectroscopic analyses, and their cytotoxic activities on four kinds of human tumor cells were studied in vitro. Compound 4 showed significant cytotoxic activity against MCF-7 and A549 with IC50 values of 6.16 +/- 2.21 and 28.5 +/- 11.5 mu M, respectively, while 5 exhibited selective cytotoxicity against A549 with an IC50 value of 13.0 +/- 4.51 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：134 / 137

页数：4

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