Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection

被引：24

作者：

Matic, Nancy ^{[1
,2
]}

Stefanovic, Aleksandra ^{[1
,2
]}

Leung, Victor ^{[1
,2
]}

Lawson, Tanya ^{[1
]}

Ritchie, Gordon ^{[1
,2
]}

Li, Lynne ^{[2
]}

Champagne, Sylvie ^{[1
,2
]}

Romney, Marc G. ^{[1
,2
]}

Lowe, Christopher F. ^{[1
,2
]}

机构：

[1] St Pauls Hosp, Providence Hlth Care, Div Med Microbiol & Virol, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada

[2] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2021年 / 40卷 / 02期

关键词：

COVID-19; SARS-CoV-2; Saliva; Nasopharyngeal; Transport; RESPIRATORY VIRUSES; SPECIMENS; SWAB;

D O I：

10.1007/s10096-020-04090-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Due to global shortages of flocked nasopharyngeal swabs and appropriate viral transport media during the COVID-19 pandemic, alternate diagnostic specimens for SARS-CoV-2 detection are sought. The accuracy and feasibility of saliva samples collected and transported without specialized collection devices or media were evaluated. Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings. SARS-CoV-2 RNA was stable in human saliva at room temperature for up to 48 h after initial specimen collection, informing appropriate transport time and conditions.

引用

页码：447 / 450

页数：4

共 50 条

[21] Serial semiquantitative detection of SARS-CoV-2 in saliva samples
Mao, Ming-Hui
Guo, Jing-Jing
Qin, Li-Zheng
Han, Zheng-Xue
Wang, Ya-Jie
Yang, Di
[J]. JOURNAL OF INFECTION, 2021, 82 (03) : 446 - 448
[22] Saliva as a possible tool for the SARS-CoV-2 detection: A review
Medeiros da Silva, Regia Carla
Nogueira Marinho, Liliane Cristina
de Araujo Silva, Davi Neto
de Lima, Kenio Costa
Pirih, Flavia Queiroz
Luz de Aquino Martins, Ana Rafaela
[J]. TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2020, 38
[23] Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2
Wyllie, Anne L.
Fournier, John
Casanovas-Massana, Arnau
Campbell, Melissa
Tokuyama, Maria
Vijayakumar, Pavithra
Warren, Joshua L.
Geng, Bertie
Muenker, M. Catherine
Moore, Adam J.
Vogels, Chantal B. F.
Petrone, Mary E.
Ott, Isabel M.
Lu, Peiwen
Venkataraman, Arvind
Lu-Culligan, Alice
Klein, Jonathan
Earnest, Rebecca
Simonov, Michael
Datta, Rupak
Handoko, Ryan
Naushad, Nida
Sewanan, Lorenzo R.
Valdez, Jordan
White, Elizabeth B.
Lapidus, Sarah
Kalinich, Chaney C.
Jiang, Xiaodong
Kim, Daniel J.
Kudo, Eriko
Linehan, Melissa
Mao, Tianyang
Moriyama, Miyu
Oh, Ji E.
Park, Annsea
Silva, Julio
Song, Eric
Takahashi, Takehiro
Taura, Manabu
Weizman, Orr-El
Wong, Patrick
Yang, Yexin
Bermejo, Santos
Odio, Camila D.
Omer, Saad B.
Dela Cruz, Charles S.
Farhadian, Shelli
Martinello, Richard A.
Iwasaki, Akiko
Grubaugh, Nathan D.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (13): : 1283 - 1286
[24] Saliva as a sample type for SARS-CoV-2 detection: implementation successes and opportunities around the globe
Tobik, Emily R.
Kitfield-Vernon, Lily B.
Thomas, Russell J.
Steel, Sydney A.
Tan, Steph H.
Allicock, Orchid M.
Choate, Brittany L.
Akbarzada, Sumaira
Wyllie, Anne L.
[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2022, 22 (05) : 519 - 535
[25] Clinical challenges of SARS-CoV-2 variants (Review)
Cojocaru, Cristian
Cojocaru, Elena
Turcanu, Adina Magdalena
Zaharia, Dragos Cosmin
[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 23 (06)
[26] SARS-CoV-2 Omicron detection by antigen tests using saliva
Murakami, Kaoru
Iwasaki, Sumio
Oguri, Satoshi
Tanaka, Kumiko
Suzuki, Rigel
Hayasaka, Kasumi
Fujisawa, Shinichi
Watanabe, Chiaki
Konno, Satoshi
Yokota, Isao
Fukuhara, Takasuke
Murakami, Masaaki
Teshima, Takanori
[J]. JOURNAL OF CLINICAL VIROLOGY PLUS, 2022, 2 (04):
[27] Saliva as a gold-standard sample for SARS-CoV-2 detection
Tan, Steph H.
Allicock, Orchid
Armstrong-Hough, Mari
Wyllie, Anne L.
[J]. LANCET RESPIRATORY MEDICINE, 2021, 9 (06): : 562 - 564
[28] Saliva as a diagnostic specimen for SARS-CoV-2 detection: A scoping review
Wang, Yifei
Upadhyay, Akshaya
Pillai, Sangeeth
Khayambashi, Parisa
Tran, Simon D.
[J]. ORAL DISEASES, 2022, 28 : 2362 - 2390
[29] Saliva screening of health care workers for SARS-CoV-2 detection
Echavarria, Marcela
Reyes, Noelia S.
Rodriguez, Pamela E.
Ricarte, Carmen
Ypas, Martin
Seoane, Alejandro
Querci, Marcia
Brizio, Marianela
Stryjewski, Martin E.
Carballal, Guadalupe
[J]. REVISTA ARGENTINA DE MICROBIOLOGIA, 2022, 54 (04): : 309 - 313
[30] Optimization and Improvement of qPCR Detection Sensitivity of SARS-CoV-2 in Saliva
Ko, Hui-Ying
Li, Yao-Tsun
Li, Ya-Yuan
Chiang, Ming-Tsai
Lee, Yi-Ling
Liu, Wen-Chun
Liao, Chun-Che
Chang, Chih-Shin
Lin, Yi-Ling
[J]. MICROBIOLOGY SPECTRUM, 2023, 11 (03):

← 1 2 3 4 5 →