Design and synthesis of photoactivatable coumarin-containing HIV-1 integrase inhibitors

被引：0
|
作者：
Zhao, H [1 ]
Neamati, N [1 ]
Pommier, Y [1 ]
Burke, TR [1 ]
机构：
[1] NCI,MOL PHARMACOL LAB,DIV BASIC SCI,NIH,BETHESDA,MD 20892
来源：
HETEROCYCLES | 1997年 / 45卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three dimeric coumarin analogues (1-3) were prepared, each containing the photoactivatable benzophenone moiety. These compounds exhibited low micromolar IC50 values against HIV-1 integrase mediated 3'-processing and strand transfer, and may represent useful probes for elucidating enzyme-inhibitor interactions.
引用
收藏
页码：2277 / 2282
页数：6
相关论文
共 50 条
  • [31] Authentic HIV-1 integrase inhibitors
    Liao, Chenzhong
    Marchand, Christophe
    Burke, Terrence R., Jr.
    Pommier, Yves
    Nicklaus, Marc C.
    [J]. FUTURE MEDICINAL CHEMISTRY, 2010, 2 (07) : 1107 - 1122
  • [32] Naphthoxazepine inhibitors of HIV-1 integrase: Synthesis and biological evaluation
    Garofalo, Antonio
    Grande, Fedora
    Brizzi, Antonella
    Aiello, Francesca
    Dayam, Raveendra
    Neamati, Nouri
    [J]. CHEMMEDCHEM, 2008, 3 (06) : 986 - 990
  • [33] The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors
    Kinzel, Olaf D.
    Monteagudo, Edith
    Muraglia, Ester
    Orvieto, Federica
    Pescatore, Giovanna
    del Rosario, Maria
    Ferreira, Rico
    Rowley, Michael
    Summa, Vincenzo
    [J]. TETRAHEDRON LETTERS, 2007, 48 (37) : 6552 - 6555
  • [34] New developments in diketo-containing inhibitors of HIV-1 integrase
    Zhao, Guisen
    Wang, Chao
    Liu, Chuan
    Lou, Hongxiang
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (07) : 707 - 725
  • [35] Novel aryl diketo-containing inhibitors of HIV-1 integrase
    Pais, GCG
    Burke, TR
    [J]. DRUGS OF THE FUTURE, 2002, 27 (11) : 1101 - 1111
  • [36] Synthesis and characterization of coumarin-containing polyphosphazene
    Liu, CM
    Qiu, JJ
    Bao, R
    Zhao, C
    Cheng, XJ
    Xu, Y
    Zhou, Y
    [J]. REACTIVE & FUNCTIONAL POLYMERS, 2006, 66 (04): : 455 - 464
  • [37] Design, synthesis, molecular modeling, and anti-HIV-1 integrase activity of a series of photoactivatable diketo acid-containing inhibitors as affinity probes
    Sechi, Mario
    Carta, Fabrizio
    Sannia, Luciano
    Dallocchio, Roberto
    Dessi, Alessandro
    Al-Safi, Rasha I.
    Neamati, Nouri
    [J]. ANTIVIRAL RESEARCH, 2009, 81 (03) : 267 - 276
  • [38] Design and synthesis of γ-keto-α-amino acid derivatives as Interfacial inhibitors of HIV-1 Integrase
    Kolluru, Srikanth
    Vince, Robert
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [39] The Design and Synthesis of Pyrolle-Carbaldehydes as HIV-1 Integrase Strand-Transfer Inhibitors
    Hewer, Raymond
    Traut, Telisha
    Williams, Bradley
    Coates, Judy
    [J]. ANTIVIRAL RESEARCH, 2011, 90 (02) : A50 - A50
  • [40] Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors
    Ramkumar, Kavya
    Yarovenko, Vladimir N.
    Nikitina, Alexandra S.
    Zavarzin, Igor V.
    Krayushkin, Mikhail M.
    Kovalenko, Leonid V.
    Esqueda, Adrian
    Odde, Srinivas
    Neamati, Nouri
    [J]. MOLECULES, 2010, 15 (06) : 3958 - 3992
12345