Novel aryl diketo-containing inhibitors of HIV-1 integrase

被引：0
|
作者：
Pais, GCG [1 ]
Burke, TR [1 ]
机构：
[1] NCI, Ctr Canc Res, Med Chem Lab, NIH, Frederick, MD 21702 USA
来源：
DRUGS OF THE FUTURE | 2002年 / 27卷 / 11期
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D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
HIV-1 integrase is a promising therapeutic target for the development of drugs to treat HIV infection. Aryl diketo-based analogs, disclosed independently by scientists from Merck and Shionogi pharmaceutical companies, are a unique class of compounds that exhibit potent integrase inhibition and display good antiviral effects in HIV-infected cells. The progress of Merck's L-870810 and Shionogi's S-1360 to phase 11 clinical trials has promised the inclusion of integrase inhibitors in "cocktail" combination therapies in the near future. This review presents a critical overview of research related to this new class of integrase inhibitors.
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页码：1101 / 1111
页数：11
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