N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines

被引：23
|
作者：
Baraldo, K
Mori, E
Bartoloni, A
Petracca, R
Giannozzi, A
Norelli, F
Rappuoli, R
Grandi, G
Del Giudice, G
机构：
[1] Chiron Vaccines, Res Ctr, I-53100 Siena, Italy
[2] Chiron Vaccines, Technol Dev, I-53100 Siena, Italy
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 08期
关键词：
D O I：
10.1128/IAI.72.8.4884-4887.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
N19, a string of human universal CD4 T-cell epitopes from various pathogen-derived antigens, was shown to exert a stronger carrier effect than CRM197 for the induction of anti-group C Neisseria meningitidis capsular polysaccharide (MenC), after immunization of mice with various dosages of N19-MenC or CRM-MenC conjugate vaccines. After two immunizations, the N19-based construct induced anti-MenC antibody and protective bactericidal antibody titers higher than those induced by three doses of the CRM-MenC conjugate and required lower amounts of conjugate. N19-based conjugates are superior to CRM-based conjugates to induce protective immune responses to MenC conjugates.
引用
收藏
页码：4884 / 4887
页数：4
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