N19 polyepitope as a carrier for enhanced immunogenicity and protective efficacy of meningococcal conjugate vaccines

被引：23
|
作者：
Baraldo, K
Mori, E
Bartoloni, A
Petracca, R
Giannozzi, A
Norelli, F
Rappuoli, R
Grandi, G
Del Giudice, G
机构：
[1] Chiron Vaccines, Res Ctr, I-53100 Siena, Italy
[2] Chiron Vaccines, Technol Dev, I-53100 Siena, Italy
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 08期
关键词：
D O I：
10.1128/IAI.72.8.4884-4887.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
N19, a string of human universal CD4 T-cell epitopes from various pathogen-derived antigens, was shown to exert a stronger carrier effect than CRM197 for the induction of anti-group C Neisseria meningitidis capsular polysaccharide (MenC), after immunization of mice with various dosages of N19-MenC or CRM-MenC conjugate vaccines. After two immunizations, the N19-based construct induced anti-MenC antibody and protective bactericidal antibody titers higher than those induced by three doses of the CRM-MenC conjugate and required lower amounts of conjugate. N19-based conjugates are superior to CRM-based conjugates to induce protective immune responses to MenC conjugates.
引用
收藏
页码：4884 / 4887
页数：4
相关论文
共 50 条
  • [21] Immunogenicity and protective efficacy study using combination of four tuberculosis DNA vaccines
    Hong Cai
    Xia Tian
    Xidan Hu
    Yi Pan
    Guoli Li
    Yuhui Zhuang
    Yuxian Zhu
    Science in China Series C: Life Sciences, 2003, 46 : 495 - 502
  • [22] Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines
    Brice, Gary T.
    Dobaño, Carlota
    Sedegah, Martha
    Stefaniak, Maureen
    Graber, Norma L.
    Campo, Joseph J.
    Carucci, Daniel J.
    Doolan, Denise L.
    MICROBES AND INFECTION, 2007, 9 (12-13) : 1439 - 1446
  • [23] Japanese encephalitis vaccines: Immunogenicity, protective efficacy, effectiveness, and impact on the burden of disease
    Hegde, Nagendra R.
    Gore, Milind M.
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2017, 13 (06) : 1320 - 1337
  • [24] Immunogenicity and protective efficacy study using combination of four tuberculosis DNA vaccines
    Cai, H
    Tian, X
    Hu, XD
    Pan, Y
    Li, GL
    Zhuang, YH
    Zhu, YX
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2003, 46 (05): : 495 - +
  • [25] Immunogenicity and protective efficacy study using combination of four tuberculosis DNA vaccines
    蔡宏
    田霞
    呼西旦
    潘怡
    李国利
    庄玉辉
    朱玉贤
    Science in China(Series C:Life Sciences) , 2003, (05) : 495 - 502
  • [26] Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine
    Zhang, Tingting
    Yu, Weili
    Wang, Yanfei
    Hu, Tao
    VACCINE, 2015, 33 (28) : 3208 - 3214
  • [27] COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety
    Fendler, Annika
    de Vries, Elisabeth G. E.
    GeurtsvanKessel, Corine H.
    Haanen, John B.
    Wormann, Bernhard
    Turajlic, Samra
    von Lilienfeld-Toal, Marie
    NATURE REVIEWS CLINICAL ONCOLOGY, 2022, 19 (06) : 385 - 401
  • [28] Safety, efficacy, and immunogenicity of COVID-19 vaccines; a systematic review
    Asghar, Neelam
    Mumtaz, Hassan
    Syed, Abdul Ahad
    Eqbal, Farea
    Maharjan, Reeju
    Bamboria, Aditya
    Shrehta, Manish
    IMMUNOLOGICAL MEDICINE, 2022, 45 (04) : 225 - 237
  • [29] COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety
    Annika Fendler
    Elisabeth G. E. de Vries
    Corine H. GeurtsvanKessel
    John B. Haanen
    Bernhard Wörmann
    Samra Turajlic
    Marie von Lilienfeld-Toal
    Nature Reviews Clinical Oncology, 2022, 19 : 385 - 401
  • [30] CAPSULAR POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES OF CARBOTYPE-1 VIBRIO-VULNIFICUS - CONSTRUCTION, IMMUNOGENICITY, AND PROTECTIVE EFFICACY IN A MURINE MODEL
    DEVI, SJN
    HAYAT, U
    FRASCH, CE
    KREGER, AS
    MORRIS, JG
    INFECTION AND IMMUNITY, 1995, 63 (08) : 2906 - 2911
12345