Mitotic drivers-inhibitors of the Aurora B Kinase

被引：52

作者：

Keen, Nicholas ^{[1
]}

Taylor, Stephen ^{[2
]}

机构：

[1] AstraZeneca, R&D Boston, Waltham, MA 02451 USA

[2] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

CANCER AND METASTASIS REVIEWS | 2009年 / 28卷 / 1-2期

关键词：

Aurora Kinase; Mitosis; Anti-mitotic; Cell-cycle; Cancer; Therapeutic; SMALL-MOLECULE INHIBITOR; SPINDLE-ASSEMBLY CHECKPOINT; GROWTH IN-VIVO; CELL-DIVISION; PHASE-II; SELECTIVE INHIBITOR; ANTITUMOR-ACTIVITY; SIRNA SCREEN; CANCER-CELLS; POLO;

D O I：

10.1007/s10555-009-9184-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this article we review the basis for current anti-mitotic, anti-cancer, therapy and the potential for Aurora B kinase inhibitors as a new differentiated class of agents-"mitotic drivers". We review the current understanding of Aurora B inhibition from basic cell biology to inhibitors currently undergoing clinical trials.

引用

页码：185 / 195

页数：11

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