Mitotic drivers-inhibitors of the Aurora B Kinase

被引：52
|
作者：
Keen, Nicholas [1 ]
Taylor, Stephen [2 ]
机构：
[1] AstraZeneca, R&D Boston, Waltham, MA 02451 USA
[2] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
CANCER AND METASTASIS REVIEWS | 2009年 / 28卷 / 1-2期
关键词：
Aurora Kinase; Mitosis; Anti-mitotic; Cell-cycle; Cancer; Therapeutic; SMALL-MOLECULE INHIBITOR; SPINDLE-ASSEMBLY CHECKPOINT; GROWTH IN-VIVO; CELL-DIVISION; PHASE-II; SELECTIVE INHIBITOR; ANTITUMOR-ACTIVITY; SIRNA SCREEN; CANCER-CELLS; POLO;
D O I：
10.1007/s10555-009-9184-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this article we review the basis for current anti-mitotic, anti-cancer, therapy and the potential for Aurora B kinase inhibitors as a new differentiated class of agents-"mitotic drivers". We review the current understanding of Aurora B inhibition from basic cell biology to inhibitors currently undergoing clinical trials.
引用
收藏
页码：185 / 195
页数：11
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