Universal reusable polymer support for oligonucleotide synthesis

被引:6
|
作者
Kumar, P [1 ]
Mahajan, S [1 ]
Gupta, KC [1 ]
机构
[1] Univ Delhi, Nucl Acids Res Lab, Inst Genom & Integrat Biol, Delhi 110007, India
来源
JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 19期
关键词
D O I
10.1021/jo049575v
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new efficient reusable universal polymer support for oligonucleotide synthesis, based on a non-ammoniacal cleavable linker, is described. Twenty six cycles of oligonucleotide synthesis have been carried out without compromising the quality of the fully deprotected oligonucleotides.
引用
收藏
页码:6482 / 6485
页数:4
相关论文
共 50 条
  • [1] A UNIVERSAL GLASS SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS
    DEBEAR, JS
    HAYES, JA
    KOLECK, MP
    GOUGH, GR
    NUCLEOSIDES & NUCLEOTIDES, 1987, 6 (05): : 821 - 830
  • [2] OLIGONUCLEOTIDE SYNTHESIS ON A POLYMER SUPPORT
    LETSINGE.RL
    MAHADEVA.V
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (15) : 3526 - &
  • [3] A new universal solid support for oligonucleotide synthesis
    Azhayev, AV
    TETRAHEDRON, 1999, 55 (03) : 787 - 800
  • [4] Introduction of a universal solid support for oligonucleotide synthesis
    ScheuerLarsen, C
    Rosenbohm, C
    Jorgensen, TJD
    Wengel, J
    NUCLEOSIDES & NUCLEOTIDES, 1997, 16 (1-2): : 67 - 80
  • [5] A conformationally preorganized universal solid support for efficient oligonucleotide synthesis
    Guzaev, AP
    Manoharan, M
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (09) : 2380 - 2381
  • [6] A novel catechol-based universal support for oligonucleotide synthesis
    Anderson, Keith M.
    Jaquinod, Laurent
    Jensen, Michael A.
    Ngo, Nam
    Davis, Ronald W.
    JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (26): : 9875 - 9880
  • [7] Rainbow(TM) universal CPG: A versatile solid support for oligonucleotide synthesis
    Nelson, PS
    Muthini, S
    Vierra, M
    Acosta, L
    Smith, TH
    BIOTECHNIQUES, 1997, 22 (04) : 752 - 756
  • [8] Elaboration of silica colloid/polymer hybrid support for oligonucleotide synthesis
    Pacard, E
    Brook, MA
    Ragheb, AM
    Pichot, C
    Chaix, C
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2006, 47 (02) : 176 - 188
  • [9] MODIFICATION OF THE H-PHOSPHONATE OLIGONUCLEOTIDE SYNTHESIS ON POLYMER SUPPORT
    EFIMOV, VA
    DUBEY, IY
    BIOORGANICHESKAYA KHIMIYA, 1990, 16 (02): : 211 - 218
  • [10] OLIGONUCLEOTIDE SYNTHESIS ON POLAR POLYMER SUPPORTS - USE OF A POLYPEPTIDE SUPPORT
    CHAPMAN, TM
    KLEID, DG
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (05) : 193 - 194