Mammary Tumorigenesis through LPA Receptor Signaling

被引：28
|
作者：
Jonkers, Jos [2 ]
Moolenaar, Wouter H. [1 ]
机构：
[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
来源：
CANCER CELL | 2009年 / 15卷 / 06期
关键词：
LYSOPHOSPHATIDIC ACID; CANCER;
D O I：
10.1016/j.ccr.2009.05.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
引用
收藏
页码：457 / 459
页数：3
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