Mammary Tumorigenesis through LPA Receptor Signaling

被引：28
|
作者：
Jonkers, Jos [2 ]
Moolenaar, Wouter H. [1 ]
机构：
[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
来源：
CANCER CELL | 2009年 / 15卷 / 06期
关键词：
LYSOPHOSPHATIDIC ACID; CANCER;
D O I：
10.1016/j.ccr.2009.05.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
引用
收藏
页码：457 / 459
页数：3
相关论文
共 50 条
  • [21] Autotaxin facilitates selective LPA receptor signaling
    Polo, Fernando Salgado-
    Borza, Razvan
    Matsoukas, Minos-Timotheo
    Marsasis, Florence
    Jagerschmid, Catherine
    Waeckel, Ludovic
    Moolenaar, Wouter H.
    Ford, Paul
    Heckmann, Bertrand
    Perrakis, Anastassis
    CELL CHEMICAL BIOLOGY, 2023, 30 (01) : 69 - +
  • [22] Inhibition of the Activity of Cyclophilin A Impedes Prolactin Receptor-Mediated Signaling, Mammary Tumorigenesis, and Metastases
    Hakim, Shawn
    Craig, Justin M.
    Koblinski, Jennifer E.
    Clevenger, Charles V.
    ISCIENCE, 2020, 23 (10)
  • [23] LPA Induces Erythropoiesis Process Through Activating LPA Receptor 3
    Chiang, Chi-ling
    Yao, Chao-Ling
    Lin, Chuan-en
    Chang, Chi-hao
    Lee, Hsinyu
    FASEB JOURNAL, 2011, 25
  • [24] The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
    Lin, Songbai
    Lee, Sei-Jung
    Shim, Hyunsuk
    Chun, Jerold
    Yun, C. Chris
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2010, 299 (05): : G1128 - G1138
  • [25] Noncanonical TGF-β Signaling During Mammary Tumorigenesis
    Parvani, Jenny G.
    Taylor, Molly A.
    Schiemann, William P.
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2011, 16 (02) : 127 - 146
  • [26] TGF-β signaling in mammary gland development and tumorigenesis
    Wakefield, LM
    Piek, E
    Böttinger, EP
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2001, 6 (01) : 67 - 82
  • [27] Stromal and epithelial TGF-β signaling in mammary tumorigenesis
    Moses, HL
    Cheng, N
    Chytil, A
    Gorska, AE
    Aakre, M
    Forrester, E
    Neilson, EG
    Bhowmick, NA
    BREAST CANCER RESEARCH, 2005, 7 (Suppl 2) : S1 - S1
  • [28] Smad-signaling in mammary gland development and tumorigenesis
    Gupta, Vandana
    Thiagalingam, Arunthathi
    Maheswaran, Shyamala
    CURRENT SIGNAL TRANSDUCTION THERAPY, 2007, 2 (02) : 111 - 120
  • [29] Noncanonical TGF-β Signaling During Mammary Tumorigenesis
    Jenny G. Parvani
    Molly A. Taylor
    William P. Schiemann
    Journal of Mammary Gland Biology and Neoplasia, 2011, 16 : 127 - 146
  • [30] TGF-β Signaling in Mammary Gland Development and Tumorigenesis
    Lalage M. Wakefield
    Ester Piek
    Erwin P. Böttinger
    Journal of Mammary Gland Biology and Neoplasia, 2001, 6 : 67 - 82
12345