Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response

被引：1

作者：

Pearson, Ewan ^{[1
]}

Thakarakkattil, Anand ^{[1
]}

Nair, Narayanan ^{[1
]}

机构：

[1] Univ Dundee, Dundee, Scotland

来源：

NATURE MEDICINE | 2022年 / 28卷 / 05期

关键词：

D O I：

10.1038/s41591-022-01791-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic heterogeneity in type 2 diabetes (T2D) was visualized by non-linear dimensionality reduction in a cohort of over 23,000 people. Variation in the T2D phenotype mapped to variation in drug response, risk of disease complications and underlying genetic architecture.

引用

页码：909 / 910

页数：2

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