Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response

被引：1
|
作者：
Pearson, Ewan [1 ]
Thakarakkattil, Anand [1 ]
Nair, Narayanan [1 ]
机构：
[1] Univ Dundee, Dundee, Scotland
来源：
NATURE MEDICINE | 2022年 / 28卷 / 05期
关键词：
D O I：
10.1038/s41591-022-01791-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phenotypic heterogeneity in type 2 diabetes (T2D) was visualized by non-linear dimensionality reduction in a cohort of over 23,000 people. Variation in the T2D phenotype mapped to variation in drug response, risk of disease complications and underlying genetic architecture.
引用
收藏
页码：909 / 910
页数：2
相关论文
共 50 条
  • [1] Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response
    Nature Medicine, 2022, 28 : 909 - 910
  • [2] Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes
    Anand Thakarakkattil Narayanan Nair
    Agata Wesolowska-Andersen
    Caroline Brorsson
    Aravind Lathika Rajendrakumar
    Simona Hapca
    Sushrima Gan
    Adem Y. Dawed
    Louise A. Donnelly
    Rory McCrimmon
    Alex S. F. Doney
    Colin N. A. Palmer
    Viswanathan Mohan
    Ranjit M. Anjana
    Andrew T. Hattersley
    John M. Dennis
    Ewan R. Pearson
    Nature Medicine, 2022, 28 : 982 - 988
  • [3] Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes
    Nair, Anand Thakarakkattil Narayanan
    Wesolowska-Andersen, Agata
    Brorsson, Caroline
    Rajendrakumar, Aravind Lathika
    Hapca, Simona
    Gan, Sushrima
    Dawed, Adem Y.
    Donnelly, Louise A.
    McCrimmon, Rory
    Doney, Alex S. F.
    Palmer, Colin N. A.
    Mohan, Viswanathan
    Anjana, Ranjit M.
    Hattersley, Andrew T.
    Dennis, John M.
    Pearson, Ewan R.
    NATURE MEDICINE, 2022, 28 (05) : 982 - +
  • [4] Visualizing drug treatment pathways in type 2 diabetes
    Patrick, Amanda R.
    Nemeth, Sheila
    Adimadhyam, Sruthi
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2019, 28 : 514 - 514
  • [5] Genetics of Drug Response in Type 2 Diabetes
    Tkac, Ivan
    CURRENT DIABETES REPORTS, 2015, 15 (07)
  • [6] Genetics of Drug Response in Type 2 Diabetes
    Ivan Tkáč
    Current Diabetes Reports, 2015, 15
  • [7] Insights into the heterogeneity of type 2 diabetes
    不详
    JOURNAL FUR ENDOKRINOLOGIE DIABETOLOGIE UND STOFFWECHSEL, 2024, 17 (01): : 36 - 36
  • [8] A Review of Treatment Response in Type 2 Diabetes: Assessing the Role of Patient Heterogeneity
    Cantrell, Ronald A.
    Alatorre, Carlos I.
    Davis, Elizabeth J.
    Zarotsky, Victoria
    Le Nestour, Elisabeth
    Carter, Debra Cuyun
    Goetz, Iris
    Paczkowski, Rosirene
    Sierra-Johnson, Justo
    DIABETES, 2010, 59 : A293 - A293
  • [9] A review of treatment response in type 2 diabetes: assessing the role of patient heterogeneity
    Cantrell, R. A.
    Alatorre, C. I.
    Davis, E. J.
    Zarotsky, V.
    Le Nestour, E.
    Carter, G. Cuyun
    Goetz, I.
    Paczkowski, R.
    Sierra-Johnson, J.
    DIABETES OBESITY & METABOLISM, 2010, 12 (10): : 845 - 857
  • [10] Interplay of Vascular Phenotype and Metabolic Phenotype in Populations With or Without Type 2 Diabetes Response to Letter by Bosevski
    Sourij, Harald
    Wascher, Thomas C.
    STROKE, 2008, 39 (11) : E176 - E176
12345