The Glu298Asp polymorphism in the NOS3 gene and the risk of prostate cancer

被引：5
|
作者：
Zhang, Yonggang [1 ]
Jia, Qingyi [2 ]
He, Qing [2 ]
Shen, Jiani [2 ]
Yang, Jiqiao [2 ]
Xue, Pei [2 ]
Ma, Mengmeng [1 ]
Xu, Rui [2 ]
Du, Liang [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 05期
关键词：
Prostate cancer; Polymorphism; NOS3; Meta-analysis; SUSCEPTIBILITY; METAANALYSIS;
D O I：
10.1007/s13277-014-1619-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Glu298Asp polymorphism in the NOS3 gene has been implicated as a risk factor for prostate cancer. To date, several studies have evaluated the associations between the Glu298Asp polymorphism and prostate cancer risk; however, the results were inconclusive. The aim of the current study was to perform a meta-analysis to investigate the association between the polymorphism and the risk of prostate cancer. A total of 3,206 cases and 3,880 controls from eight case-control studies were included for data synthesis. The overall results suggested no significant association between the polymorphism and the risk of prostate cancer (OR=1.01, 95 % CI=0.92-1.11, p = 0.83 for Asp/Asp+Glu/Asp vs. Glu/Glu). In the stratified analysis according to ethnicity, no significant associations were observed in Asians and Europeans. The current meta-analysis suggested that the Glu298Asp polymorphism of the NOS3 gene might not contribute to the risk of prostate cancer.
引用
收藏
页码：4735 / 4739
页数：5
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