Association of eNOS Glu298Asp gene polymorphism with circadian blood pressure rhythm

被引：2

作者：

Ormezzano, O.

Amar, J.

Vehier, C. Mounier

Cambien, F.

Poirier, O.

Chamontin, B.

Francois, P.

Mallion, J-M

Baguet, J-P

机构：

[1] CHU Michallon, Serv Cardiol & Hypertens Arterielle, Grenoble, France

[2] CHU Purpan, Serv Med Interne & Hypertens Arterielle, Toulouse, France

[3] CHU Lille, Serv Cardiol, F-59037 Lille, France

[4] Univ Paris 06, INSERM, U525, Paris, France

[5] CHU Michallon, Dept Veille Sanit, Grenoble, France

来源：

JOURNAL OF HUMAN HYPERTENSION | 2007年 / 21卷 / 06期

关键词：

D O I：

10.1038/sj.jhh.1002169

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertensive patients with altered circadian blood pressure (BP) profile experience greater repercussion of hypertension on target organs and a higher risk of cardiovascular events, compared with those with physiological variations in BP. It has been demonstrated in animal models, that circadian variations in BP depend on several regulatory systems, in particular the nitric oxide-cGMP(1) pathway. eNOS298 Glu/Asp polymorphism is a functional variant and may alter the amount of NO generated or eNOS activity. 2 The objective of the present study was to find out whether eNOS298 gene polymorphism affects circadian BP regulation in 110 healthy subjects and 155 never-treated hypertensive patients recruited at Hypertension Units in Grenoble, Toulouse and Lille (France).

引用

页码：501 / 503

页数：3

共 50 条

[1] Association of eNOS Glu298Asp gene polymorphism with circadian blood pressure rhythm
O Ormezzano
J Amar
C Mounier Vehier
F Cambien
O Poirier
B Chamontin
P François
J-M Mallion
J-P Baguet
[J]. Journal of Human Hypertension, 2007, 21 : 501 - 503
[2] Association of ENOS GLU298ASP gene polymorphism with circadian blood pressure rhythm.
Ormezzano, Olivier
Amar, Jacques
Mounier-Vehier, Claire
Cambien, Francois
Poirier, Odette
Chamontin, Bernard
Francois, Patrice
Mallion, Jean-Michel
Baguet, Jean-Philippe
[J]. JOURNAL OF HYPERTENSION, 2006, 24 : 281 - 281
[3] Association of eNOS gene polymorphism (Glu298Asp) with psoriasis
Senturk, Nilgun
Kara, Nurten
Aydin, Fatma
Gunes, Sezgin
Yuksel, Esra Pancar
Bagci, Hasan
Turanli, Ahmet Yasar
[J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 44 (01) : 52 - 55
[4] Association of eNOS Glu298Asp gene polymorphism with ischemic stroke in Turkish patients
Guldiken, B.
Sipahi, T.
Guldiken, S.
Ustundag, S.
Turgut, N.
Budak, M.
Ozkan, H.
[J]. EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 : 66 - 66
[5] Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians
Srivastava, Kamna
Narang, Rajiv
Sreenivas, V.
Das, Sabri
Das, Nibhriti
[J]. CLINICA CHIMICA ACTA, 2008, 387 (1-2) : 80 - 83
[6] Glu298Asp eNOS polymorphism is not associated with SLE
Mucenic, T.
Brenol, J. C. T.
Bredemeier, M.
dos Santos, B. Paiva
Chies, J. A. B.
Monticielo, O. A.
Xavier, R. M.
[J]. LUPUS, 2009, 18 (05) : 448 - 451
[7] The Relationship between eNOS Glu298Asp Polymorphism and the Changes of Blood Pressure and Induced by Metoprolol
Liu, L. W.
Han, L. L.
Chen, G. L.
Liu, H.
Liu, Y. Q.
Li, Y. S.
[J]. CARDIOLOGY, 2010, 117 : 124 - 124
[8] eNOS Glu298Asp gene polymorphism in the cases of idiopathic thrombocytopenic purpura
Arslan, F.
Akarsu, S.
Kara, M.
Ustundag, B.
Yuce, H.
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 867 - 867
[9] Glu298Asp polymorphism of the eNOS gene is associated with coronary collateral development
Gulec, Sadi
Karabulut, Halil
Ozdemir, Aydan Ongun
Ozdol, Cagdas
Turhan, Sibel
Altin, Timucin
Tutar, Eralp
Genc, Yasemin
Erol, Cetin
[J]. ATHEROSCLEROSIS, 2008, 198 (02) : 354 - 359
[10] The functional consequence of the GLU298ASP polymorphism of the eNOS gene in humans.
Lang, CC
Chan, S
Godfrey, V
Butler, R
Cassidy, AJ
Fardon, T
Choy, A
Struthers, AD
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 79 (02) : P65 - P65

← 1 2 3 4 5 →