A convenient synthesis of 1,4-disubstituted imidazoles

被引：35

作者：

He, Y ^{[1
]}

Chen, YZ ^{[1
]}

Du, HW ^{[1
]}

Schmid, LA ^{[1
]}

Lovely, CJ ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 28期

基金：

美国国家卫生研究院;

关键词：

imidazoles; regioselective; protection; isomerization;

D O I：

10.1016/j.tetlet.2004.05.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the regioselective protection of 4-alkyl-, 4-iodo, 4-vinylimidazoles has been developed via all alkylation-isomerization sequence with various imidazole-protecting groups. The initially formed mixture of 4/5-alkyl-, 4/5-iodo, and 4/5-vinylimidazoles are isomerized to the corresponding 4-isomers on treatment of a DMF solution with a small amount of RX and heating at 75degreesC. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5529 / 5532

页数：4

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